Baeyer-Villiger氧化手性损失?做一个Baeyer-Villiger氧化,文献方法如下: A solution of oxindole 16a (38 mg, 0.10 mmol, 88% ee) in DCM (1 mL) was treated with NaHCO3 (20 mg, 0.24 mmol, 2.4 equiv) and m-CPBA (49 mg, 0.20 mmol, 2 equiv). The solution was heated to reflux.The reaction was monitored by TLC and allowed to cool after consumption of the starting material (8 h). The excess peracid was quenched with NaHSO3 (sat., 1 mL) and stirred for 10 min. The solution was diluted with H2O (10 mL) and DCM (10 mL) and the layers were separated. The aqueous layer was extracted with DCM (2x, 10 mL) and combined organic layers were washed with NaHCO3 (sat., 10 mL), dried (MgSO4), filtered and condensed.查看更多3个回答 . 13人已关注