新人第一帖：求助四氮杂环与乙二醛的反应？忘记把文献放上去了，是这个 A methanolic solution of 25 mmol of glyoxal (40% aqueous) was added dropwise, between -5 and 0 ℃, to a cooled methanolic solution of 25 mmol of the tetraazamacrocycle (cyclen, cyclam or homocyclam). The mixture was stirred for 3 h at room temperature. After solvent evaporation, the residue was dissolved in Et2O and the solution filtered to remove polymers. After evaporation of the solvent, bis-aminals were isolated as white solids and used as such in the following steps. 95% yield, mp=94℃（？） ---------New J. Chem., 2001, 25, 1168-1174查看更多
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