标签：荧光抗体 古朵生物 肌营养蛋白α抗体

  肌营养蛋白α抗体的应用方法有哪些?

  英文名称 Dystrobrevin alpha

  中文名称 肌营养蛋白α抗体

  供应商 古朵生物

  别 名 Dystrobrevin alpha; DRP3; DTN; DTNA; Dystrophin related protein 3; FLJ96209; LVNC1; OTTHUMP00000163154; OTTHUMP00000163155; D18S892E; DTN-A; DTNA_HUMAN.

  研究领域 细胞生物 免疫学 神经生物学

  抗体来源 Rabbit

  克隆类型 Polyclonal

  交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,

  产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500肌营养蛋白α抗体 (石蜡切片需做抗原修复)

  not yet tested in other applications.

  optimal dilutions/concentrations should be determined by the end user.

  分 子 量 63kDa

  细胞定位 细胞浆

  性 状 Lyophilized or Liquid

  浓 度 1mg/1ml

  免 疫 原 KLH conjugated synthetic peptide derived from human DRP3

  亚 型 IgG

  纯化方法 affinity purified by Protein A

  储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

  保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

  肌营养蛋白α抗体产品介绍 background:

  Dystrobrevin alpha belongs to the dystrobrevin subfamily of the dystrophin family. It is a component of the dystrophin associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha and beta dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin alpha may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Mutations in Dystrobrevin alpha are associated with left ventricular noncompaction with congenital heart defects.

  Function:

  Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration .

  Subunit:

  Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.

  Subcellular Location:

  Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.

  Tissue Specificity:

  Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

  Post-translational modifications:

  Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.

  肌营养蛋白α抗体的应用方法有哪些? 上海古朵生物科技有限公司成立于上海浦东新区。是一家专门从事生物技术相关产品，励志研发和销售的综合性生物公司，产品远销多个国家和地区，我们将一如既往地秉承“一切为了满足客户的需求”的经营宗旨;牢固树立“以客户需求为准则、以市场需求为导向，不断开发高质量的新产品，提供客户满意的综合服务质量”的方针。