4-Fluoro-2-methoxyphenol, also known as 4-氟-2-甲氧基苯酚, is a light yellow transparent liquid at room temperature and pressure, with significant acidity. It has poor solubility in water and low-polarity organic solvents but is easily soluble in organic solvents such as N,N-dimethylformamide and dimethyl sulfoxide. 4-Fluoro-2-methoxyphenol is a phenol derivative with general physical and chemical properties of phenol substances. It can react with chlorosilanes under alkaline conditions to obtain siloxane derivatives, mainly used as chemical synthesis intermediates and basic materials for pesticide chemistry, with some applications in the synthesis of fluorinated phenol pesticides.

What are the physical and chemical properties?

The phenolic hydroxyl group in the structure of 4-Fluoro-2-methoxyphenol exhibits strong acidity. It can be transformed into the corresponding phenol oxyanion under the action of medium-strong bases. This oxyanion can undergo nucleophilic substitution reactions with common nucleophilic reagents such as alkyl halides, which can be used for the preparation of phenol ether derivatives.

What is the siloxanization reaction?

Figure 1 Siloxanization reaction of 4-Fluoro-2-methoxyphenol

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What are the chemical applications?

4-Fluoro-2-methoxyphenol is widely used as an organic synthesis intermediate in the field of chemical synthesis, and can be used to prepare various functional compounds. It can be used to synthesize fluorinated phenol organic molecules with specific structures and functions through different chemical reaction pathways such as esterification, acylation, amination, etc.

References

[1] Hadden, M. Kyle; et al Journal of Organic Chemistry 2009,74,4697-4704.