人脐静脉内皮细胞提取物是从人原代脐静脉内皮细胞提取的,用于基因克隆、表达图谱分析以及各种分子生物学实验的研究。这些细胞是从正常人脐静脉内皮组织制备的,采集工作根据IRB和HIPAA批准的方案进行。
脐静脉是胎儿生长发育过程中的重要血管,通过将来自母体的氧气和营养成分输入胎儿血液循环中,保证胎儿的生长发育。人脐静脉内皮细胞在血管内皮细胞实验中被广泛应用,而不是直接采用静脉血管内皮细胞或动脉血管内皮细胞。
高血糖可以损伤血管内皮细胞功能,导致糖尿病血管病变的发生。硫化氢(H2S)是一种重要的气体信号分子,具有广泛的生物学效应,并显示出治疗性应用前景。研究表明,人脐静脉内皮细胞提取物可以保护高糖诱导的人脐静脉内皮细胞损伤,并通过抑制炎症、氧化应激等途径发挥作用。
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