Dast及Deoxofluor取代羟基时，手性中心的变化？ bis(2-methoxyethyl)aminosulfur trifluoride (deoxo-fluor reagent) is a new deoxofluorinating agent that is much more thermally stable than dast (c 2 h 5 ) 2 nsf 3 . it is effective for the conversion of alcohols to alkyl fluorides, aldehydes and ketones to the corresponding gem-difluorides, and carboxylic acids to the trifluoromethyl derivatives with, in some cases, superior performance compared to dast. g. s. lal, g. p. pez, r. j. pesaresi, f. m. prozonic, h. cheng, j. org. chem. , 1999 , 7048-7054. deoxo-fluor is a versatile and mild reagent for acyl fluoride generation and subsequent one-flask amide coupling. the conversion of acids to amides and weinreb amides and the use of deoxo-fluor as peptide-coupling reagent have been explored. products are isolated by facile purification in good to excellent yields. j. m. white, a. r. tunoori, b. j. turunen, g. i. georg, j. org. chem., 2004 , 69 , 2573-2576. 复制代码 [此贴子已经被作者于2008-1-30 16:04:59编辑过] 查看更多
第1天
关注盖德视界
添加小助手
