求助！！SOS，异烟酸甲酯还原成4-吡啶甲醇？ 硼氢化钠换成硼氢化钾（效果一样，还经济），然后调节一下反应时间和温度应该可以 这个体系我用过，经过调节感觉效果很好， 或者你可以参考以下的过程试一下 preparation of (2-chloro-4-pyridinyl)methanol borane-dimethyl sulfide complex (14.30 ml, 14.30 mmols) was added to tetrahydrofuran solution of 2-chloroisonicotinic acid (17.56 g, 11.5 mmols) under cooling with ice, and stirred at room temperature for 2.5 days, followed by further an hour’s stirring at 50°c. cooling the reaction liquid to room temperature, ethyl acetate was added, followed by washing with saturated aqueous ammonium chloride solution and saturated brine and drying over anhydrous sodium sulfate. concentrating the solvent under reduced pressure, the title compound (15.0 g, 93%) was obtained.查看更多
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