【求助】请问苯环上的氰基如何还原?Preparation of 1-N,N-dimethylaminomethyl-4-aminomethylbenzene: To a solution of 1-N,N-dimethyl aminomethyl-4-carbonitrile benzene (4.8 g, 30 mmol) in THF is added a solution of 1 M borane tetrahydrofu ran complex (90 mL). The mixture is heated at reflux temperature for 16 hours under nitrogen. After cooling to room temperature, a 1M solution of HCl in methanol (100 mL) is added. The reaction mixtur e is heated at reflux for 3 hours. The product, which precipitates, is collected by filtration, washed with diethyl ether, and dried in vacuo to give 5.9 g (83percent yield) of the product as the hyd rochloride salt (Compound (i)): 1H NMR (DMSO-d6) delta 8.65 (br s, 3H), 7.55 (dd, 4H), 4.25 (s, 2H), 3.98 (s, 2H), 2.62 (s, 6H). 产率：83%查看更多
Doxorubicin hydrochloride原料2019版日本药典标准？Japanese Pharmacopoeia Japanese Pharmacopoeia (JP) is established and published to regulate the properties and quality of drugs by the Minister of Health, Labour and Welfare after hearing the opinion of the Pharmaceutical Affairs and Food Sanitation Council (PAFSC). The JP consists of General Notices, General Rules for Crude Drugs, General Rules for Preparations, General Tests, Processes and Apparatus and Official Monographs. Items selected for entry in the JP must be those important in health care based on the necessity of the drug in medical practice, wide application and experience of use. Since it was first published in June 1886, the JP has been revised many times periodically. The 17th edition of the JP came into effect on April 1, 2016. The Japanese Pharmacopoeia 17th edition PDF The Japanese Pharmacopoeia 17th edition（March 7, 2016 The MHLW Ministerial Notification No. 64） PDF Table of errata PDF Supplement I of the 17th edition(December 1, 2017 The MHLW Ministerial Notification No.348) Supplement Ⅱ of the 17th edition(June 28, 2019 The MHLW Ministerial Notification No.49)查看更多
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