大家看看这个合成方法的原理是什么？摘自 Org Lett？ 以下是引用 lightfeather 在2007-2-6 14:07:00的发言： 我怎么老觉得有问题。 n -(2-amino-ethyl)-3,5-di- tert -butylbenzylamine: in a dry 50 ml round bottom flask was added 3,5-di- tert -butyl benzoic acid (2.0 g, 8.5 mmol), carbonyldiimidazole (1.4 g, 10 mmol), and 30 ml of anhydrous ch 3 cn. the reaction was stirred for 20 min under ar at room temperature. in a separate dry 50 ml round bottom flask, fitted with an addition funnel, was placed 6 ml of ethylenediamine. the activated 3,5-di- tert -butylbenzoic acid was transferred to the addition funnel and added dropwise to the ethylenediamine over 1 h with rapid stirring. after 3 h, the reaction was extracted with 5% hcl / chcl 3 (3 x 100 ml), and the organic layers were collected, dried over mgso 4 , and solvent was removed in vacuo . the crude material was separated on silica using chcl 3 containing 5% meoh. to obtain the free amine, the product was extracted with 2n naoh / chcl 3 (3 x 100 ml), and the organic layers were combined and dried with mgso 4, affording the desired product (2.3 g, 8.2 mmol) in 97% yield as a white solid: 这不是很简单的一个东西，苯甲酸的羧基用cdi活化后与乙二胺偶联，你觉得有什么问题啊 查看更多
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