急，急，急。。。求助谁能查默克索引，查熔点、溶解度 cas号145108？Title: Dexmedetomidine CAS Registry Number: 113775-47-6 CAS Name: 4--1H-imidazole Additional Names: d-medetomidine Manufacturers' Codes: MPV-1440 Molecular Formula: C13H16N2 Molecular Weight: 200.28 Percent Composition: C 77.96%, H 8.05%, N 13.99% Literature References: a2-Adrenergic agonist; (+)-isomer of medetomidine, q.v. Prepn: A. J. Karjalainen et al., GB 2206880; eidem, US 4910214 (1989, 1990 both to Farmos). Physical properties: R. Rajala et al., Eur. J. Pharm. Sci. 1, 219 (1994). Clinical pharmacokinetics: P. Talke et al, Anesth. Analg. 85, 1136 (1997). Clinical evaluation as anesthetic adjunct: J. Jalonen et al., Anesthesiology 86, 331 (1997). Review of pharmacology and clinical experience for sedation of patients in intensive care: N. Bhana et al., Drugs 59, 263-270 (2000). Derivative Type: Hydrochloride CAS Registry Number: 145108-58-3 Trademarks: Precedex (Abbott) Molecular Formula: C13H16CN2.HCl Molecular Weight: 248.75 Percent Composition: C 67.60%, H 6.89%, N 11.26%, Cl 14.25% Properties: White or almost white crystalline powder, mp 156.5-157.5°. d 1.17 g/cm3. +52.4° (c = 1 in water). pH of 1% soln in water: 4.3. Melting point: mp 156.5-157.5° Optical Rotation: +52.4° (c = 1 in water) Density: d 1.17 g/cm3 Therap-Cat: Sedative; analgesic. Keywords: a-Adrenergic Agonist; Sedative/Hypnotic. Source: Merck Index 14th查看更多
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