Pschorr 反应. 重氮盐在碱性条件下发生分子内的 ...？ 这个反应没见过。不过手头有一个文献，是氨基重氮化后直接跟苯反应成联苯的例子，是个分子间的反应，你可以参考下。 A solution of 96 grams (0.50 mole) of crude 4-bromo-2-fluoroaniline and 60.0 grams (1.0 mole) of glacial acetic acid in 100 ml of benzene is added dropwise over 7 hours to a mixture of 69.0 grams (1.0 mole) of sodium nitrite, 69 ml water, and 700 ml of benzene kept at 65 degree. The mixture is then allowed to stir at 65 degree overnight (12 hours) under a nitrogen atmosphere. The cooled mixture is washed twice with 400 ml of 1 N hydrochloric acid, then heated under reflux overnight (13 hours) with 20 grams (0.36 mole) of iron powder, 250 ml of methanol, and 150 ml (1.8 moles) of concentrated hydrochloric acid. The resultant solution is cooled and the benzene layer is washed with 490 ml of water, and evaporated at 40 degree /40 mm Hg. The resultant dark oil is distilled at 10 mm Hg pressure to obtain 64.6 grams (51.5%) of 4-bromo-2-fluorobiphenyl 借鉴方法就是将原料溶解在乙酸中，滴加到亚硝酸钠水溶液中，祝你好运。查看更多
第1天
关注盖德视界
添加小助手
