求助选择性HDAC3抑制剂RGFP966研究进展？不知道这个能不能帮到你 里面提到The compound showed good PK/PD relationship and good exposure time in phase 1b clinical trials, and it is now in the planning stages for phase 2b trials. 另外一个比较新一点的报道 https://www.tandfonline.com/doi/abs/10.1080/13543776.2017.1262350 里面提到however, in the 700 mg dose group reversible transaminase elevations were observed in four patients, which prompted the company to cancel testing VTP-43742 at a initially planned third, higher dose. In Vitae Pharmaceuticals latest patent applications, WO2016061160 and US20160122345, potential dihydropyrrolopyridine back-up compounds of clinical candidate VTP-43742 (covered in WO2015116904) are disclosed. 还有待考证吧查看更多
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