奈伟拉平(VIRAMUNE)结构式? non-nucleoside reverse transcriptase inhibitor (nnrti) of the dipyridodiazepinone class. prepn: k. d. hargrave et al., ep 429987 (1991 to boehringer, ing; thomae); eidem, us 5366972 (1994 to boehringer, ing.); eidem, j. med. chem. 34, 2231 (1991). inhibition of hiv-1 reverse transcriptase: v. j. merluzzi et al., science 250, 1411 (1990). studies of structure-activity and binding site: p. m. grob et al., aids res. hum. retroviruses 8, 145 (1992). clinical pharmacokinetics: s. h. cheeseman et al., antimicrob. ag. chemother. 37, 178 (1993). review of clinical experience: a. carr, d. a. cooper, adv. exp. med. biol. 394, 299-304 (1996); of safety profile: r. b. pollard et al., clin. ther. 20, 1071-1092 (1998). clinical trial in prevention of perinatal hiv-1 transmission: l. a. guay et al., lancet 354, 795 (1999). n h n n n h 3 c o n h n n n h 3 c o [此贴子已经被作者于2005-11-21 9:28:54编辑过] 查看更多
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