请教硝基还原方法? 请参考,其他的方法也可以,自己查吧 methyl 4-amino-6-bromo-3-chloropyridine-2-carboxylate to a solution of titanium tetrachloride (0.015 mol, 2.8 g) in tetrahydrofuran (50 ml) was added lithium aluminum hydride (0.0175 mol, 0.7 g). the black slurry was stirred 15 min before adding methyl 6-bromo-3-chloro-4-nitropyridine-2-carboxylate, n-oxide (0.007 mol, 2.3 g) in thf (25 ml). the solution was stirred 1 hr before pouring into 1:1 h.sub.2 o/nh.sub.4 oh and filtering. the filtrate was extracted with etoac (2.times.75 ml). the organic phase was dried (na.sub.2 so.sub.4), and concentrated. the red solid was chromatographed over silica in 4:1 etoac/hexane to give methyl 4-amino-6-bromo-3-chloropyridine-2-carboxylate (0.003 mol, 0.8 g); mp 194-5.degree. c. .sup.1 h nmr(cdcl.sub.3): .delta. 3.95 (3h, s), 5.3 (2h, bs), 6.9 (1h, s).查看更多