Jim Watson：总结近年抗转移性肿瘤药物研发的进展？好厉害的一个老头，八十几岁高龄了还有这么大的能量，最近他写了一篇关于抗转移性肿瘤药物研发的综述，视野之广实为罕见，不愧为DNA之父。 目录如下，简单翻译了一下，感性趣的话下载 Oxidants, antioxidants and the current incurability of metastatic cancers 1. Summary 概述 2. Molecular pathways to cancer as revealed through DNA sequencing 通过DNA序列揭秘癌症细胞信号通路 3. Epithelial-to-mesenchymal transitions are a consequence of changes in transcriptional regulation 上皮-间质细胞转型是转录调节改变的结果 4. IL6-like cytokines drive mesenchymal cells to commence cell proliferation IL-6样 细胞因子 驱动间质 细胞增殖 5. The gene transcription activator Myc allows cells to move through the cell cycle 基因转录激活子Myc促使细胞离开正常生命周期 6. Bromodomain 4 proteins play essential roles in maintaining the Myc levels necessary for leukaemic cell growth and division 溴结构域蛋白4（BRD4）在维持Myc水平，保证血癌细胞生长与分裂方面起重要作用 7. Mycis turned on through multiple molecular pathways 多条信号通路可以激活Myc 8. Detecting key cancer cell vulnerabilities through RNAi screens 通过RNAi筛选发现癌细胞弱点 9. BRD4 functioning is vital not only for fast-growing leukaemias but also for many, if not most, dangerous lymphomas and myelomas BRD4不仅是血癌细胞快速生长的关键，而且也是严重淋巴瘤、骨髓瘤的关键点 10. The circadian rhythm regulator (PER2) by negatively regulating Myc levels functions as an important tumour suppressor 昼夜节律调节子（PER2）通过负调控Myc水平而抑制肿瘤 11. High-Myc-driven, fast proliferating cells possess cell cycle vulnerabilities 高水平Myc驱动的细胞增殖在细胞周期上存在弱点 12. Selectively killing cancer cells through exploiting cancer-specific metabolic and oxidative weaknesses 利用癌细胞特异性的代谢和氧化弱点，选择性杀死癌细胞 13. Preferential cancer cell killing by apoptosis reflects high p53 levels 癌细胞凋亡反映高的水平p53 14. P53 induces apoptosis by turning on the synthesis of genes whose primary function is the synthesis of reactive oxygen species P53通过激活活性氧自由基相关基因的合成而诱导细胞凋亡 15. Leakage from drug-impaired mitochondrial electron transport chains raises reactive oxygen species levels 药物阻断线粒体电子传递链引起细胞内活性氧自由基的升高 16. Reactive oxygen species may directly induce most apoptosis 活性氧自由基直接诱导大多数细胞凋亡 17. Blockage of reactive-oxygen-species-driven apoptosis by antioxidants 抗氧化剂 能阻断活性氧自由基驱动的细胞凋亡 18. Enhancing apoptotic killing using pre-existing drugs that lower antioxidant levels 砒霜能降低抗氧化剂水平而增强细胞凋亡自杀 19. Anti-angiogenic drugs work only when used in conjunction with reactive oxygen species generators 抗血管生成药物只有与活性氧自由基产生剂连用才有效 20. Lower reactive oxygen species levels in stem cells reflect higher levels of antioxidants 干细胞中活性氧自由基水平很低，而抗氧化剂水平很高 21. Metformin selectively targets (kills) mesenchymal cancer stem cells 二甲双胍能选择性杀死间质癌干细胞 22. Free-radical-destroying antioxidative nutritional supplements may have caused more cancers than they have prevented 有自由基清除作用的抗氧化营养补充剂可能诱导癌症 23. A much faster timetable for developing anti-metastatic drugs 我们迫切需要抗肿瘤转移药物 24. A billion dollars should suffice to identify all the remaining proteins needed for curing most metastatic cancer 十亿美元足以鉴定治疗大多数转移性肿瘤所需的蛋白查看更多2个回答 . 2人已关注
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