大家看看我的这个反应哪里出了问题？ 实际上咪唑是催化剂作用，我前贴说错了，其他催化剂也是可以的。 a commercially available proazaphosphatrane is an efficient and mild catalyst for the silylation of a wide variety of alcohols and phenols, including acid-sensitive, base-sensitive, and hindered substrates, using tert -butyldimethylsilyl chloride (tbdmscl). the reactions are carried out in acetonitrile from 24 to 40°c and on rare occasions in dmf from 24 to 80°c. although representative primary alcohols, secondary alcohols, and phenols were silylated using the more sterically hindered reagent tert -butyldiphenylsilyl chloride (tbdpscl), tertiary alcohols were recovered unchanged. b. a. d'sa, d. mcleod, j. g. verkade, j. org. chem. , 1997 , 62 , 5057-5061. tris(pentafluorophenyl)borane, b(c 6 f 5 ) 3 , is an effective catalyst for a mild and efficient dehydrogenative silation of alcohols using a variety of silanes. only the most bulky silanes (bn 3 sih and i r 3 sih) were not reactive under these conditions. generally, the reactions are clean and high yielding, with dihydrogen as the only byproduct. primary aliphatic alcohols are silated cleanly but slowly, whereas secondary and tertiary alcohols react more rapidly. the reaction tolerates many functional groups inlcuding alkenes, alkynes, aliphatic ketones, esters, furans, and nitro. the selectivity of the silation reactions are roughly governed by the relative basicity of the present functional groups with more basic groups being selectively silated. the mechanism is discussed. j. m. blackwell, k. l. foster, v. h. beck, w. e. piers, j. org. chem. , 1999 , 64 , 4887-4892. 查看更多
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