想做MEK1/ERK/NF-KB信号通路的WB,进口抗体选哪家的好?Nuclear factor kappa beta (NF-kB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and thereby cell function. The pathway is activated by a variety of stimuli, including cellular stress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial/viral infection.Activated NF-kB translocates to the nucleus, where it binds to specific sequences of DNA called response elements. This DNA/NF-kB complex then recruits RNA polymerase and other coactivators, which transcribe downstream DNA into mRNA for protein synthesis.Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. 查看更多
用了酸酐，加热微微回流，结果发生了脱羧。请问要用什么做脱水剂?不是很理解在问什么. 1.不是脱羧 2.看起来酸酐活化了一个羧酸, 成mixed anhydride, the other carboxylic acid attack the mixed anhydride to form the new intermediate acid anhydride, and then the N of the amide group attack the mixed anhydride to yield the product.查看更多
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