有什么好方法对手性的苯乙胺进行外消旋化? 先形成schiff碱，再脱掉．．．see: method for producing racemic phenethylamines. stelzer, uwe. (bayer a.-g., germany). ger. offen. (1998), 12 pp. coden: gwxxbx de 19629692 a1 19980129 patent written in german. application: de 96-19629692 19960723. priority: . can 128:167308 an 1998:79714 caplus atent family information atent no. kind date application no. date de 19629692 a1 19980129 de 1996-19629692 19960723 wo 9803465 a1 19980129 wo 1997-ep3691 19970711 au 9736223 a 19980210 au 1997-36223 19970711 ep 923534 a1 19990623 ep 1997-932809 19970711 ep 923534 b1 20001004 r: be, ch, de, dk, es, fr, gb, it, li, nl br 9710391 a 19990817 br 1997-10391 19970711 cn 1226228 a 19990818 cn 1997-196707 19970711 jp 2000514813 t 20001107 jp 1998-506503 19970711 es 2150267 t3 20001116 es 1997-932809 19970711 il 127970 a 20010826 il 1997-127970 19970711 us 6046351 a 20000404 us 1999-230232 19990119 riority application de 1996-19629692 a 19960723 wo 1997-ep3691 w 19970711 abstract racemic phenethylamines i [r1-r5 = h, halo, cyano, nitro, alkyl, alkoxy, alkylthio, alkylsulfinyl, etc.] are prepd. by condensing their optically active stereoisomers with acetophenone derivs. ii, treating the resulting optically active schiff base [optically active iii] with metal hydroxide contg. 0.1-50% water, and treating the resulting racemic schiff base with acid in the presence of water. thus, (s)-1-(4-chlorophenyl)ethylamine was treated with 4-chloroacetophenone in toluene contg. tetra-bu orthotitanate at room temp. followed by refluxing 6 h to give 91% the corresponding (s) schiff base, which was stirred with koh contg. 15 wt.% water for 16 h and then heated at 130-160° followed by cooling and refluxing with 2n aq. h2so4 for 2 h to give the title compd. (±)-1-(4-chlorophenyl)ethylamine. _ 查看更多
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