卤代苯腈和氯硅烷反应？ 还在搞这个课题？ A dry, 250-mL, three-necked flask equipped with an argon inlet and a stirring bar is charged with 4-bromobenzonitrile (9.1 g, 50 mmol) (Note 4) and evacuated for 5 min. The flask is flushed with argon, dry tetrahydrofuran (THF, 100 mL) (Note 5) is added, and the flask is equipped with an internal thermometer. The solution is cooled to −100°C in a diethyl ether/liquid nitrogen bath and left for 5 min before slowly adding butyllithium (BuLi, 32 mL, 1.56 M in hexanes, 50 mmol) (approx. 20 min). After complete addition the mixture is stirred at −100°C for an additional 30 min before it is allowed to warm to −78°C. 查看更多
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