请问如何防止对氨基苯甲醛自缩合?The compound 苯甲酰氯14 (0.02 mol) in anhydrous ethyl acetate (10 mL) was added dropwise to a solution of p-aminobenzaldehyde 13 in dried ethyl acetate (0.02 mol, 40 mL) and K2CO3 (0.05 mol, 3.24 g) at room temperature. After 4-6 h, water (50 mL) was poured into the reaction flask and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried and evaporated to give crude product. The crude material was chromatographed on silica gel using petroleum ether/ethyl acetate (4:1 v/v) as eluent to afford the pure product 15a-15c. 出自Asian Journal of Chemistry (2015), 27, (2), 491-495.查看更多
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