苯环上的羟基卤代的反应？ 可以使用 pocl3， pcl5，socl2合成，产率应该可以上60%。文献请看综述chemical reviews (washington, dc, united states), 49, 273-412; 1951 有条件还可以试试氯气： journal of organic chemistry, 55(10), 3415-17; 1990 general procedure. chlorine gas (10 g, 142 mm) is bubbled into phenylphosphorus dichloride (18.6 ml, 142 mm) at such a rate as to maintain the reaction temperature at 70-80 "c. after the chlorine addition is complete, the resulting molten pptc is a clear yellow liquid. phenol (13.4 g, 142 mm) is added on one portion, and the reaction mixture is heated to 160 "c overnight. the cooled reaction mixture is then poured onto crushed ice/water (200 ml) and neutralized with 50% aqueous sodium hydroxide. after extraction with ether, the combined ether extracts are dried and distilled to give chlorobenzene (12.1 g, 76%) as a colorless liquid. 查看更多
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