求助脱除N-叔丁基喹啉酸上叔丁基的方法？ 我不是用reaxys给你查了吗? 在二氯甲烷中加三氟乙酸 example name 22.1 example title ethyl 6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate step 1 ethyl 6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate a solution of ethyl 1-tert-butyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (4.00 g, 11.8 mmol) in ch2cl2 (20 ml) and trifluoroacetic acid (4.0 ml) was stirred at 0.deg. c. for 30 min. the mixture was concentrated in vacuo and poured into 500 ml of ice-water. the resulting precipitate was removed by filtration, washed with water and then dried to yield ethyl 6,7-difluoro-1,4- dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (3.34 g, quant) as a colorless solid. 1h-nmr (400 mhz, dmso-d6) δ1.27 (3h, t, j=7.3 hz), 4.13 (3h, d, j=2.4 hz), 4.22 (2h, q, j=7.3 hz), 7.71 (1h, dd, j=11.0, 7.9 hz), 8.38 (1h, s), 12.23 (1h, brs). with trifluoroacetic acid in dichloromethane, time= 0.5h, t= 0 °c patent; cociorva, oana; li, bei; szardenings, katrin; fukuda, yasumichi; nomura, masahiro; seto, shigeki; yumoto, kazuhiro; okada, kyoko; nakamura, ayako; us2007/254866; (2007); (a1) english查看更多
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