求助关于aspen的安装问题？ [发帖奇遇]: aquilani玩宠物乐园, 获得威望720点. 刚刚按照pdf的教程认认真真的装了一遍。还是出现那个问题。而且发现装了软件之后在标题栏右下角自动出来一个open sql server service manager这个图标。。。 郁闷了。。。谢谢楼上的了查看更多
请问sonofashira 偶联要注意什么呢？无水要求严格吗？ 供参考： 如果实在搞不定，用三乙胺或者二乙胺做溶剂试试，无水条件一般，但是一定要氮气保护（cui） 。（虽然文献说无水无氧），如果加无机碱，最好加些相转移催化剂 sonogashira coupling this coupling of terminal alkynes with aryl or vinyl halides is performed with a palladium catalyst, a copper(i) cocatalyst, and an amine base. typically, the reaction requires anhydrous and anaerobic conditions, but newer procedures have been developed where these restrictions are not important. mechanism recent literature the first applications of carbene ligands in cross-couplings of alkyl electrophiles: sonogashira reactions of unactivated alkyl bromides and iodides m. eckhardt, g. c. fu, j. am. chem. soc. , 2003 , 125 , 13642-13643. modified palladium-catalyzed sonogashira cross-coupling reactions under copper-, amine-, and solvent-free conditions y. liang, y.-x. xie, j.-h. li, j. org. chem. , 2006 , 71 , 379-381. application of recoverable nanosized palladium(0) catalyst in sonogashira reaction . li, l. wang, h. li, tetrahedron , 2005 , 61 , 8633-8640. copper- and ligand-free sonogashira reaction catalyzed by pd(0) nanoparticles at ambient conditions under ultrasound irradiation a. r. gholap, k. venkatesan, r. pasricha, t. daniel, r. j. lahoti, k. v. srinivasan, j. org. chem. , 2005 , 70 , 4869-4872. efficient copper-free pdcl2(pcy3)2-catalyzed sonogashira coupling of aryl chlorides with terminal alkynes c. yi, r. hua, j. org. chem. , 2006 , 71 , 2535-2537. copper-free sonogashira coupling reaction with pdcl 2 in water under aerobic conditions b. liang, m. dai, j. chen, z. yang, j. org. chem. , 2005 , 70 , 391-393. sonogashira coupling reaction with diminished homocoupling a. elangovan, y.-h. wang, t.-i. ho, org. lett. , 2003 , 5 , 1841-1844. carbamoyl-substituted n -heterocyclic carbene complexes of palladium(ii): application to sonogashira cross-coupling reactions r. a. batey, m. shen, a. j. lough, org. lett. , 2002 , 1411-1414. single-isomer tetrasubstituted olefins from regioselective and stereospecific palladium-catalyzed coupling of β-chloro-α-iodo-α,β-unsaturated esters a. b. lemay, k. s. vulic, w. w. ogilvie, j. org. chem. , 2006 , 71 , 3615-3618. the coupling of acid chlorides with terminal alkynes using one equivalent of triethylamine under sonogashira conditions followed by subsequent addition of amines or amidinium salts to the intermediate alkynones allows a straightforward access to enaminones and pyrimidines under mild conditions and in excellent yields. a. s. karpov, t. j. j. müller, synthesis , 2003 , 2815-2826. [此贴子已经被作者于2008-8-1 16:52:39编辑过] 查看更多
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