请教手性反转? 各位朋友,谁做过关于手性翻转的实验。我这个反应文献都是JACS的,而且都是一个机构的发表的。分别在1994年和1995年。文献时一模一样的。但是我 重复 不出来。JACS可信度应该说是很高的。 文献是 Sodium metal (19 g, 0.80 g atom) was added in small portions to 450 mL of methanol at 0 度. Enantiomerically pure cis-ester acid 12 (就是底物25 g, 0.13 mol) in 40 mL of methanol was added to the sodium methoxide solution, and the resulting solution was heated at reflux for 5 days. The methanol was removed in vacuo, and the remaining white solid was cooled to 0 度, dissolved in H20 (200 mL), and acidified to pH 2 using concentrated HCl. The mixture was extracted with ethyl acetate (3 x 200 mL), washed with brine (300 mL), dried over MgS04, and concentrated. The crude trans- ester acid 13 (24 g, 96%) was isolated as a yellow oil. 我的问题是首先我的底物是否翻转我不知道,因为我无法检测。送LCMS酯就水解了。文献后处理明显有问题,旋干加水,那 甲酯 不就水解了吗? 求解其他途径进行手性翻转 谢谢查看更多19个回答 . 4人已关注