有机合成路线设计竞赛6? 科普一下最后一步 chromium oxidation or dauben–michno oxidation chromium can oxidize allylic alcohols to alpha-beta unsaturated ketones on the opposite side of the unsaturated bond from the alcohol. this is via a concerted hetero-claisen reaction, although there are mechanistic differences since the chromium atom has access to d- shell orbitals which allow the reaction under a less constrained set of geometries. 最新一期的canadian journal of chemistry里的一篇文章里用到了这个反应。 查看更多