羟基和MSCl反应中的问题,求大佬指教？各位大佬，我想问一下为什么我的这个反应做MS取代的时候，所产生的点非常的杂，实验条件如下：反应底物是2- 噻吩甲醇 （The crude alcohol was dissolved in anhydrous CH2Cl2 and stirred at 0 °C. Mesyl chloride (1.2 equiv, 12 mmol) was added dropwise via syringe under a N2 atmosphere at the same temperature followed by the addition of triethylamine (1.3 equiv, 13 mmol) dropwise. The reaction mixture was stirred for 30 min at the same temperature and then stirred at room temperature for 1−3 h until the alcohol was consumed. The reaction mixture was extracted with dichloromethane (3 × 50 mL) and water (50 mL). The organic parts were combined and dried over Na2SO4. The solvent was evaporated with a rotary evaporator, and the crude was used for the next step without further purification），我就是按这个条件来做的，点板很杂，会是什么原因呢，会不会是我的底物不稳定呢？之前做TS取代的时候点也很杂。 ()U(X8GRK)U1$4K32Y_JPVQ.png查看更多6个回答 . 14人已关注
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