如何拆分它？ 欧洲专利对这个化合物的拆分讲得很清楚：wo2006/53441 example text example 3; preparation of ($is)-alpha-ethyl-2-oxo-l-pyrrolidineacetic acid (i?)-alpha- methylbenzylamine salt; a solution of (i?)-alpha-methylbenzylamine (106 g) and triethylamine (89 g) in toluene (100 ml) was added to a suspension of (i?is)-alpha-ethyl-2-oxo-l- pyrrolidineacetic acid (300 g, 1.75 mol) in toluene (il). the mixture was heated until complete dissolution, cooled to room temperature and stirred for 3 hours. the solids were filtered and rinsed with toluene (300 ml) to give 250 g of (is)-alpha-ethyl-2-oxo-l- pyrrolidineacetic acid (i?)-alpha-methylbenzylamine salt. the solids were crystallized from toluene and 205 g (yield 41percent) of ()s)-alpha-ethyl-2-oxo-l -pyrrolidineacetic acid (i?)-alpha-methylbenzylamine salt was obtained. the isolated solid was treated with hydrochloric acid solution and the enantiomerically pure (is)-alpha-ethyl-2-oxo-l~ pyrrolidineacetic acid could be isolated in 90percent yield. [此贴子已经被作者于2007-7-9 12:45:52编辑过] 查看更多
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