weinreb酰胺还原？ to a solution of the n -methyl- o -methyl amide (1.65 g, 3.06 mmol) in thf (30 ml) at ? 78 ° c was added dibal-h (2.90 ml of a 1.5 m solution in toluene, 4.35 mmol). after the reaction was stirred for 45 min, a saturated solution of potassium sodium tartrate (100 ml) was added and the mixture extracted with ether. the combined organic layers were dried, filtered, and concentrated. purification by flash chromatography afforded 1.37 g (93%) of the aldehyde as a colorless oil. reference: j. org. chem . 2003 , 68 , 4215–4234. 查看更多
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