求助 羟基转化为氨基 条件、反应机理？ one pot conversion of alcohols to amines synth commun 30(12), 2233-2237 (2000) experiments: a mixture of alcohol (2 mmol), sodium azide (2.4 mmol) and pph3 (4.2 mmol) in 10 ml of ccl4-dmf (1:4) was warmed at 90癈 with stirring. after total disappearance of starting material (monitored by tlc), reaction mixture was brought to rt and quenched by adding 5 ml of water. after stirring for 10 min., reaction mixture was diluted with ether (25 ml) and washed thoroughly with water. by trituration of ether fraction at 0癈, triphenylphosphineoxide was crystallized out and ether was filtered off. dried over anhydrous na2so4, filtration and concentration of solvent afforded amines almost in pure form, which were passed through a short pad of silica gel to give pure amines.查看更多
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