求助2-氯甲基吡嗪的合成？ 芳环上有氮原子的，旋干似乎不稳定，在溶剂中还是稳定，可以过柱，成盐 2-methylpyrazine (1 g) was dissolved in carbon tetrachloride (50 ml) under nitrogen. n-chlorosuccinimide (1.42 g) and benzoyl peroxide (50 mg) were added and the mixture was heated at reflux for 24 h. the reaction mixture was cooled and filtered through celite and the filtrate was concentrated in vacuo. the resulting oil was purified on silica using 30percent ethyl acetate in petrol. 1 h nmr (360 mhz, cdcl3) d 4.72 (2h, s, ch2 cl), 8.56 (2h, s, arh), 8.76 (1h, s, arh). 查看更多
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