【讨论】关于俄罗斯今年上市的一个新药？Dacarbazine From Wikipedia, the free encyclopedia Jump to: navigation, search Dacarbazine Systematic (IUPAC) name 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide Identifiers CAS number 4342-03-4 ATC code L01AX04 PubChem 2942 DrugBank APRD00331 ChemSpider 10481959 Chemical data Formula C6H10N6O Mol. mass 182.18 SMILES eMolecules & PubChem Pharmacokinetic data Bioavailability ? Metabolism ? Half life 5 hours Excretion 40% renal (unchanged) Therapeutic considerations Pregnancy cat. C Legal status ℞ Prescription only Routes IV Y(what is this?) (verify) Dacarbazine (da-KAR-ba-zeen) (brand names DTIC, DTIC-Dome; also known as DIC or Imidazole Carboxamide) is an antineoplastic chemotherapy drug used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. Antineoplastic drugs are drugs which interfere with cell growth and impede the formation of new tissue - in this case, tumor tissue. These drugs are also known as cytotoxic drugs. Dacarbazine belongs to the family of chemicals known as alkylating agents. Dacarbazine is normally administered by injection (a shot) or intravenous infusion (IV) under the immediate supervision of a doctor or nurse. Contents 1 History 2 Side effects 3 Common uses 4 Experimental 5 Suppliers 6 See also 7 Sources History See also: History of cancer chemotherapy Dacarbazine gained FDA approval in May 1975 as DTIC-Dome. The drug was initially marketed by Bayer. Side effects Like many chemotherapy drugs, dacarbazine may have numerous serious side effects, because it interferes with normal cell growth as well as cancer cell growth. Among the most serious possible side effects are birth defects to children conceived or carried during treatment; sterility, possibly permanent; or immune suppression (reduced ability to fight infection or disease). Dacarbazine is considered to be highly emetogenic, and most patients will be pre-medicated with antiemetic drugs like palonosetron or aprepitant. Other significant side effects include headache, fatigue and occasionally diarrhea. Common uses As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin lymphoma, and in the MAID regimen for sarcoma. Experimental Dacarbazine + Oblimersen. In clinical trials for malignant melanoma. Suppliers Bayer continues to supply DTIC-Dome. There are also generic versions of dacarbazine available from APP, Bedford, Mayne Pharma and Sicor (Teva).查看更多
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