cif出现B类和C类错误如何解释？审稿人提出了B类和C类错误，该怎么合理解释，求大神帮忙！谢谢 The following ALERTS were generated. Each ALERT has the format test-name_ALERT_alert-type_alert-level. Click on the hyperlinks for more details of the test. Alert level B PLAT093_ALERT_1_B No su’s on H-atoms, but refinement reported as . mixed PLAT601_ALERT_2_B Structure Contains Solvent Accessible VOIDS of . 198 A**3 Alert level C ABSTY03_ALERT_1_C The _exptl_absorpt_correction_type has been given as none. However values have been given for Tmin and Tmax. Remove these if an absorption correction has not been applied. From the CIF: _exptl_absorpt_correction_T_min 0.826 From the CIF: _exptl_absorpt_correction_T_max 0.886 PLAT232_ALERT_2_C Hirshfeld Test Diff (M-X) Zn1 -- O3 .. 7.3 su PLAT242_ALERT_2_C Check Low Ueq as Compared to Neighbors for C39 PLAT244_ALERT_4_C Low ’Solvent’ Ueq as Compared to Neighbors of Cl1 PLAT341_ALERT_3_C Low Bond Precision on C-C Bonds ............... 0.0093 Ang 以下是合成路线图： QQ图片20190212132502.png查看更多1个回答 . 20人已关注
埃博拉病毒与猪高致病性蓝耳病毒致病机理相似性比较及一种可能的埃博拉病毒治疗方案？埃博拉病毒与猪高致病性蓝耳病毒致病机理相似性比较及一种可能的埃博拉病毒治疗方案 一、埃博拉病毒与猪高致病性蓝耳病毒致病机理相似性比较 埃博拉病毒感染人的病理过程与高致病性蓝耳病毒（猪繁殖及呼吸障碍综合征病毒）感染猪的病理过程有很多相似之处，现比较分析如下： 1猪蓝耳病病毒在病毒分类上属动脉炎病毒属，埃博拉病毒不在这一属中，但动脉炎病毒属中包括猴出血热病毒，猴出血热病毒只感染猴，对猴的致病机理过程与埃博拉病毒相似。 2高致病性蓝耳病毒主要感染猪的巨噬细胞和单核细胞等免疫功能细胞，以及血管内皮细胞、肝脏和肺脏细胞。这与埃博拉病毒感染过程相似。虽然埃博拉病毒在人类的主要感染部位不是肺脏（埃博拉病毒要感染肺部的巨噬细胞，肺上皮细胞似乎不感染），但扎伊尔型埃博拉病毒感染猪主要表现肺炎症状。 3高致病性蓝耳病毒感染猪，在猪表现高热不退，呕吐和腹泻，内脏出血（肠道粘膜出血，器官表面出血点），脾脏和肝脏肿大出血坏死，皮下出血点、皮疹、心肌炎、关节炎肌肉痛，肺炎。除了肺炎这一症状，埃博拉在人体表现不明显外，其它同蓝耳病毒感染猪的病理过程基本一致。 4高致病性蓝耳病毒感染猪的单核细胞和巨噬细胞，这些细胞释放大量 细胞因子 和免疫因子，使炎症联级放大，高热不退，血管通透性增高出血，肝肾功能紊乱，是猪死亡的直接原因。埃博拉病毒致人死亡也是类似的机理。 二、一种可能的埃博拉病毒治疗方案 高致病性蓝耳病在猪只能用疫苗来预防，如果猪一旦发生感染，则病情严重、极速死亡，各种治疗方案基本无效，只能采用保守的维持疗法，预后不良，我们过去也是这样认为。 我们是主要从事植物挥发油医学应用研究，用于人类和猪的呼吸系统疾病防控，挥发油产品是放在环境中自行挥发，通过空气吸入呼吸道起作用的。 2013年6月，中国四川绵阳地区出现猪高致病性蓝耳病疫情，一个偶然的因素，我们发现：将这种挥发油产品直接涂抹在病猪的鼻梁上，发现其对猪高致病性蓝耳病有快速的治愈效果，这种作用是立杆见影的，病猪在6天时间内都快速康复了。 2013年6-8月期间，我们在绵阳地区，广泛应用了这种临床治疗方法，证明这种植物挥发油对猪高致病性蓝耳病的治疗效果是快速、高效和稳定的。 2014年7-8月期间，中国河北部分地区发生猪高致病性蓝耳病疫情，我们用同样方法进行了临床研究，得出了相同的结论。 我们的产品成分是多种植物挥发油的混合物，放置环境或涂抹鼻梁使用，呼吸道吸入挥发油，现在还不清楚其快速治愈猪高致病性蓝耳病的具体作用机制，我们确定挥发油中某个成分能直接杀死病毒，少量病毒在体内死亡有助于免疫系统对其识别并产生抗体。我们研究植物挥发油这方面的医学应用技术，已经进行了十年时间，主要目的是用于人和猪的呼吸系统疾病防控，相关产品的实际推广应用已经有4年时间，这个产品对人体和猪都没有毒害或副作用，产品应用安全。 我们的目的是希望提供这种植物挥发油配方产品用于埃博拉病毒的治疗研究，确定其是否有效。敬请有关组织、部门联系我们，免费索取产品。叶平博士TEL：13990105793；Email:3098616923@qq.com Similarity comparison of pathogenesis of ebola virus and highly pathogenic blue-ear virus and a possible ebola virus treatment Part One: Similarity comparison of pathogenesis of ebola virus and highly pathogenic blue-ear pig virus There have much in common about the pathogenesis and pathological process between the ebola virus for people and highly pathogenic blue-ear virus (porcine reproductive and respiratory syndrome virus, PRRS) for pig. Now, the comparative analysis is as follows: 1. Blue-ear disease virus belongs to arteritis virus on the classification of virus, and ebola virus is not in this genus. But arteritis virus genus contains a monkey hemorrhagic fever virus, the virus infect only monkey, the infected monkey's pathogenesis process is similar to the ebola virus. 2. Highly pathogenic blue-ear virus mainly infected pigs, including macrophages, monocytes immune cells, vascular endothelial cells, liver and lung cells. It is similar to infection process of the ebola virus. Although the main infection site of ebola virus was not human lung (ebola virus infected macrophages in the lungs, lung epithelial cells do not seem to infection), but the Zaire ebola virus can infect pig and mainly manifest pneumonia symptoms. 3. Infected pig by highly pathogenic blue-ear virus showed high fever, vomiting and diarrhea, internal bleeding (intestinal mucosal bleeding, organ surface bleeder), spleen and liver enlargement hemorrhage, necrosis, subcutaneous haemorrhage, skin rashes, myocarditis ,arthritis, muscle pain, pneumonia. In addition to the symptoms of pneumonia, the pathological processes of ebola for human body are basically identical. 4. Highly pathogenic blue-ear virus infect mononuclear cells and macrophages, and the cells release a large number of cell factors and immune factors, and the factors make inflammation and high fever, increase vascular permeability, result in liver and kidney dysfunction. It is the direct cause of death in pigs. The ebola virus shows a similar mechanism. Part two: A possible treatment for ebola virus Highly pathogenic blue-ear disease in pigs can only use the vaccine to prevent. Once the infection occurs, pigs are severe, speed death, various treatment is invalid, can only adopt conservative maintenance therapy, and a bad prognosis. We also think so in the past. We mainly engaged in the study of plant volatile oil medical applications, used in human and swine for control and prevention respiratory disease. The volatile oil plays a role in control and prevention disease through air inhalation of respiratory tract. In June of 2013, Sichuan Mianyang region in China appears highly pathogenic PRRS. An accidental opportunity, we found that the volatile oil has fast healing effect on highly pathogenic PRRS when it was daubed on the nose of sick pigs. Sick pigs were quickly recovered in 6 days time. During 6 to 8 months in 2013, we widely applied to the clinical treatment for highly pathogenic PRRS in Mianyang region. It proved that treatment effect of plant volatile oil for highly pathogenic PRRS was rapid, efficient and stable. During July and August, 2014, highly pathogenic PRRS broke out in parts of Hebei province in China, we used the same methods for the diseases, there drew same conclusions. Composition of our product is a mixture of many kinds of plant essential oil, and it is used for prevention and control PRRS by placing the environment or daubing the pig nose. We also do not know the specific mechanism of action, but we determine the composition of the volatile oil can directly kill the virus, and a small amount of DEAD virus in the body helps the immune system to recognize and produce antibodies. We study the medical technology of volatile oils for ten years, and aims at the swine respiratory disease control and prevention. The practical application of related products is over four years, and the products are secure, no toxic or side effect to pig and human body. Our purpose is to want to provide this kind of plant volatile oil formula products for the treatment of the ebola virus research, maybe it is effective. Relevant organizations, departments, contact us, please for free products. Dr. Ye Ping. TEL: 13990105793; Email:3098616923@qq.com 2014.10.17查看更多5个回答 . 17人已关注
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