正丁基锂的使用问题? 我要做一个实验要用到 正丁基锂 拔氢,但是文献上说直接加入正丁基锂,之后在60℃搅拌3小时,之后再冷却到-78℃。 我担心不会出现什么问题吧?正丁基锂不是一般都在-78℃加入、反应吗? 请高手解答疑惑! 附原文: Naphthalene (0.77 g, 6 mmol) was stirred with 9.2mL of hexane containing 24 mmol butyllithium and 3.6 mL (12 mmol) of TMEDA at 60°C for 3 hours.The resulting dark brown suspension of the lithio derivatives was allowed to cool to -78°C and was diluted with 25 mL of THF. Resublimed sulfur (1.6g, 50 mmol) was added to the suspension. The resulting orange mixture was warmed to 25°C and allowed to stir for 12 hours. It was then washed with water and the organic layer was separated and dried over anhydrous MgSO4. 摘自:Heteroatom Chemistry. Volume 5, Number 2, 1994查看更多4个回答 . 5人已关注