美国最新药物专利 (公布日：20091203)？ 1 US20090299081 Asymmetric Synthesis of Rocaglamides via Enantioselective Photocycloaddition Mediated by Chiral Bronsted Acids=通过对映选择的光环合加成反应, 以手性布郎斯台德酸非对称合成楝酰胺 The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical generation of an oxidopyrylium species from a 3- 2 US20090299078 SPECIFICALLY TAILORED ENDOHEDRAL METALLOFULLERENES=特殊的内嵌金属富勒烯 Disclosed are several different processes that can be utilized to prepare endohedral metallofullerenes with specific characteristics. Processes can be utilized to prepare monoadducts including cycloaddition of functional groups to the [6,6 3 US20090299077 Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)- -1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan=(R)-5- (2-苯磺酰乙烯基)-3-(N-甲基吡咯烷-2-基甲基) -1-H-吲哚，5-溴代=3- [(R)-1甲基-吡咯烷-2基甲基]-1-H 吲哚和依来曲普坦的盐 The present invention relates to salts of (R)-5-(2-phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole of the formula: ##STR00001##wherein HX is an acid selected from para-toluene sulfonic acid, benzene sulphonic acid, tr 4 US20090299076 Axially asymmetric ester compound and production method thereof=轴向非对称的酯化合物和其制造方法 To provide an axially asymmetric optically active biaryl ester compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. There is provided a method for producing an axi 5 US20090299075 PROCESS FOR PRODUCING MUSCARINE RECEPTOR ANTAGONIST AND INTERMEDIATE THEREFOR=毒蕈碱受体拮抗剂及其中间体的制造方法 The industrial production of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutanamide, a urinary incontinence remedy, necessitates elimination of problems concerning the use of a synthetic adsorbent, e.g., HP-20, the efficiency of operation with t 6 US20090299074 BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION=苯并[b]噻吩衍生物及其制造方法 The invention provides benzo[b]thiophene derivatives useful as production intermediates for chymase inhibitors, and a process for their production.The invention relates to benzo[b]thiophene derivatives represented by the following formula, 7 US20090299073 Process for the Manufacture of Epoxybutanol Intermediates=环氧丁醇中间体的制造的工艺 Disclosed is a process for the manufacture of a Compound of formula (I) wherein Hal represents fluoro or chloro, and R1 and R2 represent, independently from one another, hydrogen or Hal; in which process a Compound of 8 US20090299072 Tetrasubstituted Benzenes=四取代苯 Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described. 9 US20090299071 TRIAZOLE DERIVATIVE OR SALT THEREOF=三唑衍生物或其盐 A triazole derivative or pharmaceutically acceptable salt thereof is provided, the triazole derivative being represented by formula (I): ##STR00001##wherein * represents an asymmetric carbon and takes R configuration or S configuration; an 10 US20090299066 TRIAZOLONE DERIVATIVES AS MMP INHIBITORS FOR THE TREATMENT OF ASTHMA AND COPD=用于治疗哮喘和慢性阻塞性肺病的间质金属 蛋白酶抑制剂 的三唑酮衍生物 The invention provides compounds of formula (I): wherein R1, R2, R3, R4, R5, X, Y, L, G1 and m have the meanings defined in the specification; processes for their preparatio 11 US20090299065 PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)-hydroxy-3-ketoester; (b) reducing the 5(S)-hydroxy-3-k 12 US20090299064 METHODS AND INTERMEDIATES FOR THE PREPARATION OF OPTIONALLY RADIO-LABELED IMATINIB =制备放射标记 伊马替尼中间体 的方法 The invention relates to new processes for the manufacture of N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}4-(3-py- ridyl)-2-pyrimidine-amine (compound of formula I, ##STR00001##new processes for the manufacture of met 13 US20090299062 THERMOSETTING COMPOUND, COMPOSITION CONTAINING THE SAME=热凝成形化合物，及含有热凝成形化合物的组合物 The object of the present invention is to provide a thermosetting compound having dielectric properties, in particular permittivity and dielectric loss, which are improved compared to prior art, a composition containing the same, and a mol 14 US20090299061 FLUORESCENCE ASSAYS WITH IMPROVED SENSITIVITY Latent fluorescent compounds, comprising a fluorescent molecule with one or more blocking groups attached and optionally one or more urea-containing groups are provided. The urea-containing group can be used to further attach one or more m 15 US20090299058 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS =3-3 二取代的羟基吲哚抑制剂 Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disord查看更多3个回答 . 1人已关注
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