请问如图这个物质怎么合成 没找到文献 能不能存在啊？Han, Xiaoyu; Chen, Fenfen; Ye, Can; Wang, Yongjiang - A solution of oxazolone 3a (27.6 mg, 0.10 mmol) in i-PrOH (5.0mL) was treated with a solution of KHSO4 (68.0 mg, 0.50 mmol) in H2O (2.5 mL) at 10 °C until the reaction was complete (TLC).The mixture was then diluted with H2O and the mixture was extracted with Et2O. The organic layers were combined, washed with sat. aq NaHCO3, dried (Na2SO4), filtered, and concentrated under reduced pressure. The residue obtained was used in thenext step without further purification.The crude aldehyde was then dissolved in MeOH (5.0 mL), andthe solution was cooled to 0 °C. NaBH4 (5.68 mg, 0.15 mmol)was added, and the mixture was stirred for 30 min. The resulting solution was diluted with brine, and the aqueous phase was extracted with Et2O (2 ×). The combined organic extracts were dried (Na2SO4), filtered, and concentrated. The residue waspurified by column chromatography (silica gel, hexane/EtOAc =4:1) to give a colorless oil; yield: 13 mg (72percent, 2 steps); D26+33.58 (c 0.7, CHCl3) . 1H NMR (400MHz, CDCl3): δ = 7.31–7.38 (m, 3 H), 7.20–7.26 (m, 2 H), 4.86(dd, J = 12.4, 6.4 Hz, 1 H), 4.71 (dd, J = 12.4, 7.0 Hz, 1 H), 3.82–3.92 (m, 2 H), 3.73 (m, 1 H), 1.75 (t, J = 5.6 Hz, 1 H). 13C NMR(100 MHz, CDCl3): δ = 136.5, 129.7, 128.5, 127.2, 77.8, 64.6,46.1. HRMS (ESI, KOAc): m/z + calcd for C9H11KNO3:220.03705; found: 220.03709.查看更多
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