请问哪位朋友有默克索引账号 帮忙查下 sofosbuvir 的性质，CAS号：1190307？Monograph ID: MONO1500010410 Title: Sofosbuvir CAS Registry Number: 1190307-88-0 CAS Name: Isopropyl (2S)-2-{methoxy}(phenoxy)phosphoryl]amino}propanoate Additional Names: 2'-deoxy-2'-fluoro-2'-methyl-5'-O-amino]phenoxyphosphinyl]uridine, 1-Methylethyl N-methoxy}phenoxyphosphoryl]-L-alaninate, GS-7977, PSI-7977 Molecular Formula: C22H29FN9O9P Molecular Weight: 529.45 Percent Composition: C 49.91%, H 5.52%, F 3.59%, N 7.94%, O 27.20%, P 5.85% Standard InChI: InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1 Copy Standard InChIKey: TTZHDVOVKQGIBA-IQWMDFIBSA-N Copy Properties White needles (from dichloromethane); mp 94—105°C. Soly in water 5.65 mg/mL (at 25 °C). Sol in chloroform, dichloromethane, dimethylsulfoxide, ethyl acetate. References Nucleoside prodrug, dosed orally. Metabolised to the active triphosphate, which inhibits hepatitis C virus (HCV) RNA-dependent RNA polymerase (NS5B), preventing HCV replication. Prepn: Sofia J. Med. Chem.53, 7202 (2010) DOI: 10.1021/jm100863x PMID: 20845908; Ross et al., WO2010135569 (2010 to Pharmasset)). NS5B inhibition in vitro: Muraikami et al.,Antimicrob. Agents Chemother.52, 458 (2008) DOI: 10.1128/AAC.01184-07 PMID: 17999967; Accumulation of triphosphate in primary hepatocytes in vitro and in vivo: Sofia et al., loc. cit.. Genotype profiling: Lam et al.,Antimicrob. Agents Chemother.56, 458 (2012) DOI: 10.1128/AAC.00054-12 PMID: 22430955. Review of clinical studies in hepatitis C:Gentile et al.,Curr. Med. Chem.20, 3733 (2013) DOI: 10.2174/09298673113209990178 PMID: 23848533. Clinical trial (in combination with ledipasvir) in cirrhotic patients and those previously unresponsive to HCV treatment: Lawitz et al.,Lancet, (2013) DOI: 10.1016/S0140-6736(13)62121-2 PMID: 24209977. Classifications Therapeutic Category: Antiviral Keywords: Antiviral查看更多
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