氢氯噻嗪杂质c？降解途径为 甲醛引起的二聚。 检索得专利，正文中： 邻位氨基与苯磺酰胺、聚甲醛关环一段 In other method, 5-chloro-2,4-disulfamyl-aniline (II) is reacted with paraformaldehyde in the presence of a mineral acid and a solvent. The mineral acid is selected from hydrochloric acid, hydrobromic acid and sulfuric acid. Hydrochlorothiazide obtained is recrystallized from water. However, the yield obtained by this process is only 46.3% which makes the process less attractive at an industrial scale. Moreover repeating this experiment, it is found that it results in the formation of dimer impurity along with Hydrochlorothiazide which is difficult to remove by conventional purification methods. 据此来看，只要把API和甲醛、少量酸催化，加热回流即可生成此物。查看更多
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