求助默克索引，哪位大神可以代查下？Monograph Number: 0008474 Title: Sevelamer CAS Registry Number: 52757-95-6 CAS Name: 2-Propen-1-amine polymer with (chloromethyl)oxirane Additional Names: allylamine polymer with 1-chloro-2,3-epoxypropane; allylamine-epichlorohydrin copolymer; poly(allylamin-co-N,N¢-diallyl-1,3-diamino-2-hydroxypropane) Literature References: Polymeric non-absorbed phosphate binder consisting of polyallylamine crosslinked with epichlorohydrin to form a hydrogel where 40% of the amines are protonated. Follows the general formula of (C3H7N.C3H5ClO)n. Binds dietary phosphate leading to increased fecal excretion, decreased absorption and decreased serum phosphorous levels. Prepd not claimed: S. R. Holmes-Farley et al., WO 9505184; eidem, US 5496545 (1995, 1996 both to GelTex). Mechanism of action: S. R. Holmes-Farley et al., J. Macromol. Sci. Pure Appl. Chem. A36, 1085 (1999). Determn of phosphate binding capacity: J. R. Mazzeo et al., J. Pharm. Biomed. Anal. 19, 911 (1999). Clinical studies in end stage renal disease: E. A. Slatopolsky et al., Kidney Int. 55, 299 (1999). Derivative Type: Hydrochloride CAS Registry Number: 152751-57-0 Manufacturers' Codes: PB-94; GT16-026A Trademarks: Renagel (Genzyme) Properties: Insol in water. Hydrophilic. Therap-Cat: Antihyperphosphatemic. Keywords: Antihyperphosphatemic.查看更多
第1天
关注盖德视界
添加小助手
