重金求助马西替坦 的原研的晶型专利及到期日？有晶型I的，但是还没时间具体检索， EMEA明确了其最稳定晶型： Several polymorphic forms have been described including different solvates. All macitentan batches manufactured so far for clinical studies and commercial purposes correspond to the same stable polymorphic form which is a true polymorph with a melting point of 135°C. It is the thermodynamically most stable form at room temperature. Long-term stability studies on several clinical and registration batches showed no polymorphic change of after up to 36 months of storage at 30 °C / 65% RH. Results of the dynamic vapour sorption of macitentan show that it is not hygroscopic.查看更多
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