这个反应是怎么发生的? < >反应过程如下：</P> < ><STRONG>2,2-dichloro-3-phenylcyclobutanone</STRONG>: To a dry 2 necked 50 ml RBF under Argon was added styrene (1.1 ml, 9.6 mmol), Zn-Cu Couple (0.69 g, 10.5 mmol) and anhydrous Et<SUB>2</SUB>O (20 ml). To this was added a solution of Cl<SUB>3</SUB>CCOCl (1.1 ml, 10.0 mmol) and POCl<SUB>3</SUB> (0.92 ml, 10.0 mmol) in Et<SUB>2</SUB>O (20 ml) over 1 hr. The resulting mixture was then refluxed for 4 hrs. The suspension was then filtered through a pad of celite which was subsequently washed with bench Et<SUB>2</SUB>O (50 ml). The organic solution was then subsequently washed with water (100 ml), saturated NaHCO<SUB>3</SUB> (50 ml), brine (50 ml) and water (50 ml). Separation from the aqueous phase and removal of all volatile organics gave a yellow oil that was purified by trap-to-trap distillation (90<SUP>o</SUP>C, 10<SUP>-3</SUP>)to give a white crystalline solid. Yield 1.6 g, 77%.</P> < > <STRONG>3-phenylcyclobutanone:</STRONG> The halogenated product above was heated in glacial acetic acid (30 ml) for 2 hrs. Standard aqueous work-up and purification by trap-to-trap distillation (85<SUP>o</SUP>C, 10<SUP>-3</SUP>) gave a clear colourless oil.</P><BR>查看更多2个回答 . 3人已关注
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