审稿人关于XPS确定Mn元素不同化学态的问题，求助！？审稿人关于XPS的问题，求助！ Q1: Given the relationship between the relative amounts of Mn3+ to Mn4+ cations on B-site and the electrical conduction, XPS analysis was performed to determine the valence state variation of cations and to quantify the Mn3+/Mn4+ ratio. However, although it is known that the chemical state identification in manganese by XPS is difficult due to the presence of a complex multiplet splitting [A-D], this has not been taken into consideration in the deconvolution of the XPS spectra for Mn 2p3/2. This disregard has affected the evaluation of the Mn3+/Mn4+ ratios for the different samples. Q2: The weak point of the paper is the part concerning the determination of relative abundances of different Mn ions using the Mn2p3/2 peak profile fitting. Surprisingly, the widths of their Mni+2p3/2 decomposition components grow with the oxidation state i, see Fig. 3. In fact, the situation is opposite. The authors mention themselves that the widths of the Mn2p3/2 peaks are in 3.2 eV MnO, 3.0 eV in Mn2O3, and 2.5 eV in MnO2. In this situation the data on relative ratios of different Mn ions concentrations obtained by Mn2p3/2 peak fitting cannot be considered reliable. The right way to perform the decomposition of the Mn2p3/2 peak would be to use the decomposition components Mni+2p3/2with fixed widths equal to the experimental ones (may be broadened taking into account present machine’s resolution). If the authors insist that their fitting is all right in spite of the above mentioned circumstances, they should give solid reasoning for this.查看更多2个回答 . 17人已关注
关于干混悬剂的几个疑问？最近做的一个品种，在FDA数据库上查到了规格那块写着：EQ 125MG BASE/5ML，剂型那边写着：FOR SUSPENSION;ORAL ，应该是干混悬剂啦，但是用法那边是这样写的Suspension: First invert the bottle and tap to loosen the powder then add a total of 60ml water in two portions, shaking after each addition until suspended. 现在问题就有了：1、既然用法是用的60ml水，为什么规格那边会提到5ml呢，难道是仅供测定用的（比如测沉降体积比？） 2、查到药物在水中的溶解度是13mg/ml，而中国药典上规定"口服混悬剂系指难溶性固体 原料药 物分散在液体介质中制成的供口服的混悬液体制剂。也包括干混悬剂或浓混悬液"，也就是说干混悬剂是针对难溶性药物的，而此药物的在水中的溶解度属于可溶等级的，做成干混悬剂剂型合理么？ 朋友们有懂的没，帮忙解答下~查看更多6个回答 . 3人已关注
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