求linifanib最新临床情况？AbbVie is developing linifanib, an orally active multi-targeted receptor tyrosine kinase inhibitor, for the treatment of cancer, including non-small cell lung cancer, breast cancer, colorectal cancer, renal cancer and hepatocellular carcinoma. Linifanib was being developed in collaboration with Genentech; however, development later reverted to Abbott. Linifanib acts as both a vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor. It has been shown to stop disease progression by limiting tumour blood-flow. Linifanib is hydrophobic, but is oxidised in the body to A 849529, a hydrophilic metabolite that includes both carboxyl and amino groups. Linifanib is in phase II development for breast, renal, colorectal and non-small cell lung cancer. The compound was being investigated in a phase III trial for hepatocellular carcinoma, but the trial has been terminated.查看更多
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