谁有默克索引账号？有大神帮忙查下富马酸喹硫平的理化性质啊?Monograph Number: 0008039 Title: Quetiapine CAS Registry Number: 111974-69-7 CAS Name: 2-thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol Additional Names: 11--1-piperazinyl]dibenzothiazepine Molecular Formula: C21H25N3O2S Molecular Weight: 383.51 Percent Composition: C 65.77%, H 6.57%, N 10.96%, O 8.34%, S 8.36% Literature References: Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Prepn: E. J. Warawa, B. M. Migler, EP 240228; eidem, US 4879288 (1987, 1989 both to ICI). HPLC and GC/MS determn in plasma: R. H. Pullen et al., J. Chromatogr. 573, 49 (1992). Series of articles on pharmacology: Psychopharmacology 112, 285-307 (1993). Clinical evaluation in schizophrenia: H. Wetzel et al., ibid. 119, 231 (1995). Review of clinical experience: B. Green, Curr. Med. Res. Opin. 15, 145-151 (1999). Derivative Type: Hemifumarate CAS Registry Number: 111974-72-2 Manufacturers' Codes: ICI-204636 Trademarks: Seroquel (AstraZeneca) Molecular Formula: (C21H25N3O2S)2.C4H4O4 Molecular Weight: 883.09 Percent Composition: C 62.56%, H 6.16%, N 9.52%, O 14.49%, S 7.26% Properties: Crystals from ethanol, mp 172-173°. Melting point: mp 172-173° Therap-Cat: Antipsychotic. Keywords: Antipsychotic; Other Tricyclics; Serotonin-Dopamine Antagonist.查看更多
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