苯基腈水解成苯甲酰胺，停留在酰胺这一步，不继续水解成羧酸，求大神指点！！！？ELI LILLY AND COMPANY - WO2004/26305, 2004, A1 Location in patent: Page/Page column 155 Combine 4- (4-FORMYL-PHENOXY)-BENZONITRILE (3.6 g, 16.1 mmol), DIMETHYLSUFOXIDE (25 mL), potassium carbonate (2.1 g, 15.2 mmol), and 3 mL of 30percent hydrogen peroxide solution. Stir 18 h at ambient temperature. Dilute with 100 mL of water, extract with ethyl acetate (3 x 100 mL). Wash the organic phase with 100 mL of water, and 50 mL of brine. Dry the organic phase over sodium sulfate, filter, and concentrate under vacuum. Purify via aBiotage Flash 40L system using 75: 25 HEXANES/ETHYL acetate as eluting solvent to give 3.0 g (77percent) of the title compound查看更多
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